The effect of modification of mixed function oxidases and inhibition of enterohepatic circulation on concentration of estrogens in plasma in laying hens (Gallus domesticus)

The rate of metabolism and recirculation contributes to the rate of excretion and to concentration in the circulation. Steroids are substrates for mixed function oxidases (MFO). Enterohepatic circulation (EHC) of estrogens prolongs the half life of estrogens. Thus, the amount of recirculation and the extent of inactivation of estrogens by MFO can influence the peripheral concentration of estrogens. The objective of this thesis was to determine the influence of altering MFO by xenobiotics and inhibition of EHC on the peripheral concentration of estrogens and on estrogen dependent functions in laying hens (Gallus domesticus).

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Animal Sciences

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Chen, Shu-Wen

Contributors dc:contributor

• Dziuk, Philip J.

• Health Sciences, Toxicology
• Biology, Animal Physiology

Statement dc:rights

• Copyright 1992 Chen, Shu-Wen

Language dc:language

eng

Identifier

AAI9215790
(UMI)AAI9215790

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/23249