Identification, characterization and amino terminal sequencing of high molecular weight soluble antigens of the human malaria parasite, Plasmodium falciparum

Plasmodium falciparum is the most lethal of four species of protozoa that cause malaria in humans. Since the blood stage of the parasite life cycle is responsible for the clinical manifestations of the disease, studies of the immune response and vaccine development to this stage are critical to decreasing the morbidity and mortality of malaria. Immunization of experimental monkeys with crude supernatant fractions obtained from in vitro culture media or partially purified fractions of culture media have been shown to protect them from malaria. Protective immunity is known to occur naturally in afflicted adolescent and adult individuals only after long-term exposure to malaria.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biochemistry

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2011

Author dc:creator

• Nichols, James Harold

Contributors dc:contributor

• Hager, Lowell P.

• Chemistry, Biochemistry
• Health Sciences, Immunology

Statement dc:rights

• Copyright 1990 Nichols, James Harold

Language dc:language

eng

Identifier

AAI9026281
(UMI)AAI9026281

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/22408