Pharmacologic investigation of the anti-inflammatory activity of cryogenine and selected benzoquinolizine derivatives

It has become apparent in recent years that many centrally active agents possess potential anti-inflammatory capabilities. The central or peripheral mechanisms of action for these agents have not been delineated nor has their clinical efficacy baan established or refuted. The centrally active drugs, cryogenine and tetrabenazine (a benzoquinolizine derivative), previously have been shown in this laboratory to inhibit certain models of induced inflammation. The present study in rats verifies the anti-inflammatory properties of cryogenic and established that a structurally related series of benzoquinolizine derivatives possessed the capability of inhibiting both exudative (carrageenan-induced pedal edema) and proliferative (cotton pellet granuloma) models of inflammation when administered orally.

Name thesis:degree_name

Doctor of Philosophy (Ph.D.)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Graduate Studies

Year dc:date.available

1972

Author dc:creator

• DeCato, Louis

Contributors dc:contributor

• Marvin H. Malone

• Anti-inflammatory agents
• Medicine and Health Sciences

Licence

• http://rightsstatements.org/vocab/NKC/1.0/

Repository record dc:identifier

https://scholarlycommons.pacific.edu/uop_etds/1789

OAI identifier oai:identifier

oai:scholarlycommons.pacific.edu:uop_etds-2788