C-Reactive Protein Polymorphism and Serum Levels as an Independent Risk Factor in Sickle Cell Disease

<p>This study explored the relationship of a dinucleotide repeat polymorphism in the intron of the CRP gene and serum CRP levels as independent risk factors for end-organ dysfunction (mild vs. severe) in adults with sickle cell disease. The pathogenesis of secondary complications of sickle cell disease is complex and poorly understood. Predicting the severity of these complications could assist in therapeutic decision-making. </p> <p>The study measured serum CRP levels and the number of CA intron repeats located on the CRP gene in 29 adults (31.74 ± 11.54 years) with sickle cell disease The hemoglobin genotypes were distributed as Hgb SS 48.6% (17 of n = 29), Hgb SC 20.0% (7 of n = 29), Sβ° 10.3% (3 of n = 29), and Sβ⁺ 6.9% (2 of n = 29). The sample was categorized as mild (n = 9) no end-organ dysfunction vs. severe (n = 21) documented end-organ dysfunction. The severe group was sub-categorized by specific organ dysfunctions, 9 with pulmonary hypertension, 6 with renal dysfunction and 6 with cerebral vascular accident. Examination of serum CRP levels found no significant association with severe end-stage organ dysfunction. There was no significant association between serum CRP level and the polymorphism. However, a significant negative correlation (<em>rho </em>= -0.401, <em>p </em>= 0.031) was found between glomerular filtration rates and CA^high repeats (≥17). </p> <p>Previous studies have found an association of genetic variations in the CRP gene polymorphism to serum CRP levels. While this pilot study found no evidence of this association, the findings provide some rationale for further investigation of the repeat polymorphism in the CRP gene and its association with renal end-organ dysfunction.</p>

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Nursing

Year dc:date.available

2008

Author dc:creator

• Chismark, Elizabeth A.

Contributors dc:contributor

• Ann K. Cashion, PhD

• Sickle cell disease
• end-organ dysfunction
• C-reactive protein
• polymorphism
• disease severity
• Amino Acids, Peptides, and Proteins
• Chemicals and Drugs
• Diseases
• Hemic and Lymphatic Diseases
• Medicine and Health Sciences

Repository record dc:identifier

https://dc.uthsc.edu/dissertations/338

OAI identifier oai:identifier

oai:dc.uthsc.edu:dissertations-1336