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Syracuse University
Peptide Corrination for the Mitigation of Nausea and Emesis in the Treatment of Type 2 Diabetes
Abstract
dc:description.abstract<p>This thesis addresses several questions focused on the activation of receptors expressed withinthe area postrema (AP) and the nucleus tractus solitarius (NTS), regions known to influence nausea and emesis. Prevention of such effects were achieved via corrination, covalent attachment to vitamin B12 (B12) or other corrin constructs, of GLP glucagon-like peptide-one (GLP-1) receptor (GLP-1R) agonists or via the use of GRASP a growth differentiation factor 15 (GDF15) glial derived neurotropic family receptor α-like (GFRAL) complex antagonist.</p>
Degree
thesis:*- Name thesis:degree_name
- Doctor of Philosophy (PhD)
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemistry
- Year
- 2021
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Tinsley, Ian
- Contributors dc:contributor
-
- Doyle, Robert P.
Subjects
dc:subject × 2Identifiers
dc:identifier.*- Repository record dc:identifier
- https://surface.syr.edu/etd/1432
- OAI identifier oai:identifier
- oai:surface.syr.edu:etd-2433