Syntheses of a Tin (IV) meso-Tetra(4-pyridyl) Porphyrin Dichloride-Tetrachlorobis (Bipy)2 Ruthenium (II) Complex and Studies of Photophysical Properties of 1-Nitropyrene

<p>Development of a photosensitizer that can work in both aerobic and anaerobic environments would increase the robustness of the cancer treatment known as photodynamic therapy. The development of a photosensitizer was first attempted by synthesizing a tin (IV) meso-tetra (4-pyridyl) porphyrin dichloride-tetrachlorobis (Bipy)₂ ruthenium (II) complex. The synthesize of the tin porphyrin was done by a method from literature and had a percent error of 31.58 and 37.31 when comparing the theoretical percentages of carbon (55.39) and nitrogen (12.92) meaning that photosensitizer was not synthesized.</p> <p> The second type of chromophore that was studied was 1-nitropyrene do determine if it can act as a possible photosensitizer. As a proof of concept, 1-nitropyrene can act as a photosensitizer by using visible light. Upon visible light irradiation 1-nitropyrene can produce ¹O₂, ȮH, and possibly NO species under aerobic conditions and can produce ȮH and possibly NO under anaerobic conditions. </p>

Name thesis:degree_name

Master of Science in Natural Science

Level thesis:degree_level

Thesis

Year dc:date.available

2018

Author dc:creator

• Sharp, Phillip

Contributors dc:contributor

• Dr. Matibur Zamadar
• Dr. Michele Harris
• Dr. Russell Franks

• Photodynamic therapy
• singlet oxygen
• hydroxy radical
• Medicinal-Pharmaceutical Chemistry
• Organic Chemistry
• Other Chemistry

Repository record dc:identifier

https://scholarworks.sfasu.edu/etds/224

OAI identifier oai:identifier

oai:scholarworks.sfasu.edu:etds-1240