Universidad de Salamanca
Valoración de la efectividad de una pauta analgésica con buprenorfina transdérmica en pacientes afectos de isquemia arterial crónica evolucionada de las extremidades inferiores: perfil genético
Abstract
[EN]The relief of pain in patients with chronic arterial ischemia is a key pillar in the treatment of this pathology, not only to improve the quality of life of patients affected, but also to provide other medical and surgical treatments of this disease. The objectives of the study are: 1. To evaluate the efficacy of buprenorphine transdermal analgesic dose for control of ischemic pain in patients with grade III-IV artery of lower extremity Fontaine, awaiting surgery or those not eligible for surgery and its impact on quality of life of these patients. 2. To evaluate the dependence of the threshold of pain and response to treatment with respect to the personal background, sex and age of the patients studied. 3. Analyze the influence of the genetic profile of patients in pain management by opioid analgesic, by studying polymorphisms of UGT2B7, CYP3A4 and OPRM1.
Author and committee
dc:creator, dc:contributor.*- Author
-
- Blanco Antona, Francisco
Subjects
dc:subject × 11Identifiers
dc:identifier.*- Identifier
- hdl:10366/76405
- OAI identifier oai:identifier
- oai:gredos.usal.es:10366/76405