TARGETING MULTI-DRUG RESISTANT PATHOGENS WITH NOVEL ANTIMICROBIAL PEPTIDES

The emergence of antibiotic resistance is a notorious problem worldwide. In the United States alone, antibiotic-resistant bacteria infect at least two million people and kill around 23,000 patients each year. Half of these infections are attributed to the bacterial pathogen, methicillin resistant Staphylococcus aureus (MRSA) according to a report published in 2013 by the Centers for Disease Control and Prevention (CDC). Similarly, S. pseudintermedius is a leading cause of opportunistic infections in pet animals and has zoonotic potential. Furthermore, the marked increase in the incidence of infections due to extensively drug-resistant and pandrug-resistant isolates of Pseudomonas aeruginosa and Acinetobacter baumannii presents an alarming challenge that necessitates the development of novel therapeutic alternatives to traditional antibiotics in order to address this scourge.

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Comparative Pathobiology

Year

2016

Author dc:creator

• Mohamed, Mohamed F.

Contributors dc:contributor

• Mohamed Seleem
• Yoon Yeo
• Lynn F Guptill-Yoran
• Ramesh Vemulapalli

• antibiotic resistance
• antiinflammatory
• Antimicrobial peptides
• biofilm
• MRSA
• pseudomonas

Repository record dc:identifier

https://docs.lib.purdue.edu/open_access_dissertations/1223

OAI identifier oai:identifier

oai:docs.lib.purdue.edu:open_access_dissertations-2439