CHD Chromatin Remodelers Promote Epigenetic Control of Development in Arabidopsis thaliana

Chromatin remodeling is a vital biological process that facilitates activation and repression of gene expression as well as compaction of large eukaryotic genomes into compact nuclei. The CHD3 family of chromatin remodelers play key roles as epigenetic modifiers and transcriptional regulators in both plants and animals. PKL is a CHD3 remodeler that represses expression of seed genes during germination in Arabidopsis. Unlike animal CHD3 remodelers, PKL does not function as a member of a multi-subunit Mi-2 NuRD complex. Instead, PKL acts as a monomer in vivo and promotes the epigenetic modification H3K27me3, which is associated with transcriptional repression of tissue-specific genes by the PRC2. Thus, PKL plays an important role in promoting tissue identity by facilitating deposition and/or maintenance of H3K27me3.

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Biochemistry

Year

2016

Author dc:creator

• Carter, Benjamin

Contributors dc:contributor

• Joe Ogas
• Stanton Gelvin
• Ann Kirchmaier
• Scott Briggs

• Arabidopsis
• Chromatin Remodelers
• H2A.Z
• H3K27me3
• PICKLE
• PKR2

Repository record dc:identifier

https://docs.lib.purdue.edu/open_access_dissertations/1209

OAI identifier oai:identifier

oai:docs.lib.purdue.edu:open_access_dissertations-2425