Role of glutamate in lead-induced toxicity: protection by N-acetylcysteine amide (NACA), a novel thiol antioxidant

"Despite several efforts to reduce lead levels in the environment, lead exposure continues to be a major public health problem, in the US today. Toxic effect of lead are mainly manifested in central nervous system (CNS) because brain acts as a reservoir for lead deposition. Lead-induced cell damage include glutamatergic component (excitotoxic cell damage arising from impaired clearance of the released glutamate), interference with calcium-mediated cellular processes, and activation of protein kinase C (PKC) resulting in oxidative stress. Chelation therapy has been a choice to reduce the body burden of lead; however chelation does not eliminate the neurotoxicity of lead...In this study we propose to evaluate the involvement of glutamatergic component in lead-induced toxicity and also to investigate a potential compound which counteracts the entire toxic phenomenon of lead"--Abstract, page iii.

Name thesis:degree_name

Ph. D. in Chemistry

Grantor

University of Missouri--Rolla

Year dc:date.available

2016

Author dc:creator

• Penugonda, Suman

• Chemistry

Repository record dc:identifier

https://scholarsmine.mst.edu/doctoral_dissertations/1683

OAI identifier oai:identifier

oai:scholarsmine.mst.edu:doctoral_dissertations-2685