A Possible Role For Prostaglandin E-B2-S as a Suppressor of Macrophage Phagocytosis

Suppression of macrophage phagocytosis of Listeria monocytogenes has been shown to be due to a low molecular weight component of spleen cell culture supernatant. The possibility that the factor could be a prostaglandin was investigated. When murine peritoneal macrophages were treated with prostaglandin E₂ (PGE₂) they phagocytized L. monocytogenes at a rate comparable to that phagocytized when treated with a low molecular weight fraction of Concanavalin A generated spleen cell culture supernatant. Suppressive activity of spleen cell culture supernatant was abrogated when supernatant was prepared in the presence of indomethacin, a prostaglandin synthetase inhibitor. These results suggest a role for PGE₂ as a modulator of macrophage phagocytosis of L. monocytogenes.

Name thesis:degree_name

Master of Science in Biology

Level thesis:degree_level

Masters

Discipline thesis:degree_discipline

Biology

Year

1986

Author dc:creator

• Hutchison, Deborah L.

Contributors dc:contributor

• Richard Myers

• Biology

Statement dc:rights

• © Deborah L Hutchison

Repository record dc:identifier

https://bearworks.missouristate.edu/theses/139

OAI identifier oai:identifier

oai:bearworks.missouristate.edu:theses-1140