Rigid registration of MR and biplanar fluoroscopy

This thesis discusses the the rigid registration of MR data and biplanar, fluoroscopic radiographs of the head, by means of an intensity-based, measure of similarity. We investigate a number of similarity measures which have been applied in other multimodal registration contexts, including that of CT-fluoroscopy registration. The similarity measures are evaluated by probing the space of transformations between the coordinate frames of an MR volume and biplanar, digitally-reconstructed radiographs (DRRs) produced from a corresponding CT volume. This method allowed us to know the "ground truth" of the registration, which could be established by proven methods for the 3D-3D CT-MR alignment. Furthermore, we propose a method of DRR production called voxel-projection which drastically reduces processing time relative even to optimized ray-casting methods. The computational efficiency of voxel-projection makes it a useful tool for the investigation of similarity measures in this 3D-2D context. Its speed may also enable 3D-2D registration methods which rely on evaluation of a similarity measure over the entirety of a DRR and model radiograph. Based on similarity measure characeristics observed in our probing experiments, and using the voxel-projection method, we adapted the uphill-simplex optimization algorithm to implement an intensity-based MR-fluoroscopy rigid registatration engine.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2000

Author dc:creator

• Cosman, Eric (Eric Richard), 1977-

Advisor dc:contributor.advisor

• William Wells, III.

• Electrical Engineering and Computer Science.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/9079

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/9079