Potential commercial application of a bi-layer bone-ligament regeneration scaffold to anterior cruciate ligament replacement

A business model was created in order to explore the commercial application of a bi-layer bone-ligament scaffold to the treatment of torn anterior cruciate ligaments (ACL) requiring replacement. The two main keys in producing the bone scaffold are triple co-precipitation of type-I collagen, chodroitin-6-sulphate, and calcium phosphate minerals and the use of lyophilization to create a network where all the materials are homogeneously dispersed and present in significant amounts. This process allows the creation of a porous network whose physical characteristics, mechanical properties, and material content can all be changed to create a scaffold that closely mimics natural bone. A collagen and chondroitin-6-sulphate scaffold is used for ligament regeneration. The ACL replacement market was chosen because it is one of the most commonly surgically repaired ligaments in the body and because all of the current treatments have drawbacks.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Materials Science and Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2006

Author dc:creator

• Li, Jessica C. (Jessica Ching-Yi)

Advisor dc:contributor.advisor

• Lorna J. Gibson.

• Materials Science and Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/37882

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/37882