Development of quantitative tools for assessment of cerebellar dysfunction

Two tools for the quantitative assessment of cerebellar dysfunction are developed and explored. One is based on a battery of laptop tests desgined for clinical use. Extensive analysis of one of the tests using a speed/accuracy trade-off shows a correlation of 0.74 with existing scoring systems. The second involves modeling the cerebellar function in arm movement as a PID controller. Initial results show trends toward asymmetry, higher values for Gk₂₁ and Gk₂₂, and lower values for Gk₁₁ and Gk₁₂ as differences between the controller gains of ataxic subjects and control subjects when analyzing the trajectories of point to point movements. Further insight into these trends may lead to a deeper understanding of the cerebellum's function and dysfunction.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Electrical Engineering and Computer Science.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2005

Author dc:creator

• Garg, Aditi

Advisor dc:contributor.advisor

• Steve G. Massaquoi.

• Electrical Engineering and Computer Science.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/33303

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/33303