Quantitative cue-signal-response analysis of EGF-induced cell migration

(cont.) curve is explained mechanistically by the results of the first study. In a final study, we investigated the phenomenological structure of CHO-EGFR cell paths using turn angle distribution and time series analyses. Increased local cell speed correlated with increased likelihood of local directional persistence, a result independent of biochemical modulation of overall cell motility. Time-based directional autocorrelations were observed that indicate an unusual non-Markov behavior in CHO migration. Overall, these studies demonstrate how biophysical analysis is an effective tool for gaining insight into the quantitative regulation of motility by intracellular signaling.

Department dc:contributor.department

Massachusetts Institute of Technology. Dept. of Chemical Engineering.

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2004

Author dc:creator

• Harms, Brian David, 1976-

Advisor dc:contributor.advisor

• Douglas A. Lauffenburger.

• Chemical Engineering.

Statement dc:rights

• M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

en_US

Handle dc:identifier.uri

http://hdl.handle.net/1721.1/28658

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/28658