Optical coherence vibrography : a quantitative tool for probing auditory and ocular biomechanics

Mechanical properties of biological tissues are inherently tied to their function. As such, they can provide direct insight into the structure and integrity of organs, and how they are affected by physiological and pathological processes. Optical coherence tomography (OCT) is a powerful imaging modality that can image the anatomy of biological tissues with near-cellular resolution. It can also be used to measure vibrations and deformations with nanometer-level sensitivity. This combination of tomography and vibrometry -- OCT vibrography -- forms a tool that is singularly positioned to quantify biomechanical behavior at the tissue scale. This thesis focuses on two promising fields of application for OCT vibrography: otology and ophthalmology. Sound-driven vibrations in the middle-ear ossicular chain and in the tympanic membrane are fundamental to hearing. Using the chinchilla ear as a model, we investigate the vibrational amplitude and phase as a function of sound frequency. Our 3-dimensional measurements reveal with unprecedented detail the modes of motion of the ossicular chain of an intact middle-ear. The ability of the cornea to focus light into a sharp image on the retina depends on its shape, which in turn is regulated by its mechanical properties. By measuring the velocity of mechanical waves, induced by an external stimulus and tracked using OCT vibrography, acoustic theory can be used to calculate the shear-elastic modulus of the corneal stroma. Our study demonstrates the first OCT-based quantification of corneal elasticity in live humans.

Name thesis:degree_name

Doctoral

Department dc:contributor.department

Harvard--MIT Program in Health Sciences and Technology

Grantor dc:publisher

Massachusetts Institute of Technology

Year dc:date.issued

2019

Author dc:creator

• Ramier, Antoine.

Advisor dc:contributor.advisor

• Seok-Hyun Yun.

• Harvard--MIT Program in Health Sciences and Technology.

Statement dc:rights

• MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission.

Licence dc:rights.uri

• http://dspace.mit.edu/handle/1721.1/7582

Language dc:language.iso

eng

Handle dc:identifier.uri

https://hdl.handle.net/1721.1/124268

OAI identifier oai:identifier

oai:dspace.mit.edu:1721.1/124268