The synthesis and pharmacological evaluation of quisqualic acid and some novel excitatory amino acid mimetics

L-Glutamic acid and L-aspartic acid are believed to be the principal initiators of excitatory synaptic neurotransmission in the mammalian central system. A number of molecules of either natural or synthetic origin have been identified as possessing agonist or antagonist properties at glutamate binding sites. One of the most potent agonist is quisqualic acid (69), and this thesis features two aspects of the synthetic organic chemistry and the pharmacology of quisqualic acid and some of its analogues.

Name dc:type.qualificationname

phd

Level dc:type.qualificationlevel

doctoral

Grantor dc:publisher.institution

London Guildhall University

Year dc:date.issued

1992

Author dc:creator

• Okonkwo, P. I.

• 500 Natural Sciences and Mathematics
• 540 Chemistry & allied sciences

Dc Identifier Grantnumber

N/A

OAI identifier oai:identifier

oai:repository.londonmet.ac.uk:2965