Effects of Diet and Stress on Gastric Lesions in Albino Rats and Guinea Pigs

<p>Studies were conducted to (1) investigate whether any protective factor is present in fresh water-cured olives or fresh cabbage as compared with the heated supplements against stress-induced gastric lesions in rats maintained on a nutritionally adequate diet for six weeks, (2) determine the relative protective factor in water-cured olives as compared with cabbage, (3) study the effect of black pepper in combination with fresh cabbage and olives and heated cabbage and olives in rats that were fed the same nutritionally adequate diet, and (4) investigate the effects of the same dietary components—cabbage and olives--on histamine- induced gastric lesions in guinea pigs fed guinea pig chow for five weeks.</p> <p>At the end of the feeding period the rats were fasted and then stressed in quantitative stress cages and the guinea pigs were fasted and then injected intraperitoneally with histamine acid phosphate to produce gastric lesions. The effect of the diets on weight gain, number of lesions, and lesion area were analyzed statistically. The rats that were fed black pepper with heated or fresh cabbage or olives had considerably more lesions and a larger lesion area than those that had no spice. They also had a significantly reduced weight gain as compared to the control group. The animals on the spiced diets also lost much of their hair while the control groups maintained white fluffy coats. When the fresh cabbage or olive diets were compared to those with heated supplements no significant effect was found in either rats or guinea pigs. However, in the guinea pig experiments, the data showed that olives were significantly protective in both number and extent of lesions when compared with cabbage.</p> <p>The rat study was done in two separate experiments under identical circumstances. However, the animals in the first experiment had a significantly greater lesion area as compared to all the animals from the second experiment. The reason for these results are not known. Further studies with animals and human beings are needed to establish the role of cabbage and olives in lesion prevention.</p>

Name thesis:degree_name

Master of Science (MS)

Level thesis:degree_level

Thesis

Discipline thesis:degree_discipline

Nutrition

Year

1970

Author dc:creator

• McKenzie, Naomi

Contributors dc:contributor

• Marjorie V. Baldwin
• Albert Sanchez
• U. D. Register
• Bernell E. Baldwin

• Animal Experimentation and Research
• Dietetics and Clinical Nutrition
• Laboratory and Basic Science Research
• Nutrition
• Stomach Ulcer; Diet Stress, Psychological

Statement dc:rights

• This title appears here courtesy of the author, who has granted Loma Linda University a limited, non-exclusive right to make this publication available to the public. The author retains all other copyrights.

Language dc:language

English

Repository record dc:identifier

https://scholarsrepository.llu.edu/etd/1433

OAI identifier oai:identifier

oai:scholarsrepository.llu.edu:etd-2205