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University of Hull
The role of n-linked glycosylation and sialylation in regulating human proteinase-activated receptor 1 and 4 expression and signalling
Abstract
dc:description.abstractProteinase-activated receptors (PARs) are a novel family of G-protein coupled receptors (GPCRs) that mediate many of the diverse biological effects of proteinases on target cells. N-linked glycosylation is a common post-translational modification in the GPCR superfamily that enables the cell to regulate protein function without recourse to the genome. Previous pharmacological studies have found that activation of hPAR-2 by mast cell tryptase can be regulated by receptor N-terminal glycosylation. However, the role of N-linked glycosylation in regulating the expression and function of other PARs is not known.
Degree
thesis:*- Name dc:type.qualificationname
- PhD
- Level dc:type.qualificationlevel
- Doctoral
- Grantor dc:publisher.institution
- University of Hull
- Year dc:date.issued
- 2008
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Xiao, Yu Pei
- Advisors dc:contributor.advisor
-
- Compton, Steven J.
- Morice, Alyn H.
Subjects
dc:subject × 1Rights
- Language dc:language
- en
Identifiers
dc:identifier.*- Identifier
- oai:hull-repository.worktribe.com:4208901
- OAI identifier oai:identifier
- oai:hull-repository.worktribe.com:4208901