University of Patras
Η σημασία των αγγειακών αλλοιώσεων του νεφρού για την υπέρταση των αρρώστων με ετερόπλευρη χρόνια πυελονεφρίτιδα: Κλινικοπαθολογική μελέτη
Abstract
dc:descriptionHistologic examination of blood vessels in scrarred and nonscarred areas of the affected kidneys from 20 pts with chronic unilateral pyelonephritis was carried out. In addition the correlation of PRA with the FENa+, MBP, and patient's age was examined, in an effort to identity the relationship between BP level, scar process and Renin-Angiotensin system. Vascular changes were greater in scarred than in the nonscarred areas, particularly in hypertensive patients. Severe vascular changes in scars were seen only in cases with hypertension. PRA was negatively correlated with MBP and with patients age (r= -0.7, p<0.05). Multiple linear regression analysis, with the severity of vascular lesion as dependent variable and the pts, age, sex, MBP, Clcr, and PRA as independent variables, reveals that age is, the main factor which determine the severity of vascular changes (p=0.05) although the contribution of MBP must not be ignored (p=0.2). Linear with two predictor variable analysis reveals pts age to be the main factor which determine the level of MBP (r=0.68, p<0.05) and not the Clcr level (r= -0.08). These results indicate that the pyelonephritic process per se is an important factor in the development of vascular changes; this effect however is influenced by the BP level and, most importantly, by age. They also indicate that the Renin-Angiotensin system was not involved in the pathogenesis of hypertension of these patients.
Degree
thesis:*- Grantor dc:publisher
- University of Patras
- Year dc:date
- 1990
Author and committee
dc:creator, dc:contributor.*- Authors dc:creator
-
- Fokaefs, Eleftherios
- Φωκαεύς, Ελευθέριος
Subjects
dc:subject × 10Rights
- Language dc:language
- gre
Identifiers
dc:identifier.*- Identifier
- 10.12681/eadd/1312
- OAI identifier oai:identifier
- oai:10442/1312