ΔΙΕΙΣΔΥΣΗ ΤΗΣ ΚΕΦΤΡΙΑΞΟΝΗΣ ΣΤΟΝ ΠΡΟΣΤΑΤΙΚΟ ΙΣΤΟ

CEFTRIAXONE, A NEW SEMISYNTHETIC PARENTERAL CEPHALOSPORIN WITH HIGH ACTIVITY AGAINST BOTH GRAM POSITIVE AND NEGATIVE ORGANISMS WAS FOUND TO HAVE UNIQUE PHARMACOKINETIC PROPERTIES WHICH ALLOWS ONCE A DAY ADMINISTRATION. CLINICAL TRIALSSHOWED ITS EXCELLENT CLINICAL EFFICACY AND SAFETY AND ALSO ITS LACK OF TOXICITY. WE USED CEFTRIAXONE IN 21 ELDERLY PATIENTS WHO WERE ADMITTED TO THE UROLOGY DEPARTMENT OF THE UNIVERSITY OF IOANNINA FOR PROSTATECTOMY. AFTER ONE SIHALE2 G I.V. ADMINISTRATION OF CEFTRIAXONE IN EACH PATIENT PROSTATECTOMY WAS PERFORMED AT 1, 2, 4, 8, 12 AND 24 HOURS IN GROUPS OF PATIENTS (3 OR 6 PATIENTS IN EACH GROUP). TO STUDY CEFTRIAXONE BLOOD CONCENTRATION THREE BLOOD SAMPLES WERE OBTAINED FROM EACH PATIENT IN DIFFERENT TIME INTERVALS. THE ASSAY OF BLOOD AND TISSUE CONCENTRATIONS WERE PERFORMED BY A BIOLOGICAL METHOD. BLOOD CONCENTRATIONS RANGED FROM 49,0 TO 100,0 MG/ML AT ONE HOUR AFTER ADMINISTRATION, WHILE THEY RANGED FROM 2,6 TO 28,0 MG/ML AT 24 HOURS. THESE CONCENTRATIONS ARE BACTERICIDAE FOR MOST SUSCEPTIBLE PATHOGENS. PROSTATIC TISSUE CONCENTRATIONS WERE FOUND IN A RANGE OF 14,9 TO 73,7 MG/ML AT ONE HOUR (M.V.: 28,9+- 22,3) AND I, 3 TO 2,0 MG/ML AT 24 H. THESE CONCENTRATIONS ARE ALSO BACTERICIDAE FOR MOST SUSCEPTIBLE TO CEFTRIAXONE ORGANISMS. SERUM AND PROSTATIC TISSUE CEFTRIAXONE HALF-LIVES WERE CALCULATED TO BE ABOUT THE SAME (6,8 HOURS). THESE FINDINGS SUGGESTS THAT CEFTRIAXONE COULD BE PROVED EFFECTIVE IN TREATING BACTERIAE INFECTIONS IN THE PROSTATIC GLAND.

Grantor dc:publisher

University of Ioannina

Year dc:date

1986

Author dc:creator

• Σταυρινάδης, Ιωάννης

• Αντιβιοτικά
• Διείσδυση
• ΘΕΡΑΠΕΙΑ ΠΡΟΣΤΑΤΙΤΙΔΩΝ
• Κεφαλοσπορίνη
• Κεφτριαξόνη
• Παθολογία
• ΠΡΟΣΤΑΤΗΣ ΑΝΑΤΟΜΙΑ
• Προστατίτιδα
• Φυσιολογία
• Antibiotic
• Ceftriaxone
• Cephalosporin
• Pathology
• PENETRATON
• Physiology
• PROSTATE ANATOMY
• Prostatitis
• Therapy
• Ιατρική και Επιστήμες Υγείας
• Βασική Ιατρική
• Κλινική Ιατρική
• Medical and Health Sciences
• Basic Medicine
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0575

OAI identifier oai:identifier

oai:10442/0575