ΑΝΕΠΑΡΚΕΙΑ ΑΥΞΗΤΙΚΗΣ ΟΡΜΟΝΗΣ: ΕΚΚΡΙΣΗ ΣΤΗ ΔΙΑΡΚΕΙΑ ΤΟΥ ΥΠΝΟΥ

THE CONCEPT OF WHETHER GROWTH HORMONE (GH) LEVELS DURING SLEEP MORE ADEQUATELY REFLECT THE STATUS OF GROWTH HORMONE SECRETION IN CHILDREN THAN THE GROWTH HORMONE PROVACATIVE TESTS IS A SUBJECT OF DEBATE AMONG PEDIATRIC ENDOCRINOLOGISTS. THEREFORE 18 CHILDREN WITH CLASSIC GROWTH HORMONE DEFICIENCY AND 11 NORMAL CHILDREN WITH SHORT STATURE WERE STUDIED TO LOOK AT THIS QUESTION. ON DAY 1, BLOOD WAS DRAWN EVERY 20 MINUTES FOR 24 HOURS THROUGH AN INTRAVENOUS CATHETER TO OBTAIN THE GH LEVELS DURING THE ENTIRE TWENTY-FOUR HOUR PERIOD. AN ELECTRO-ENCEPHALOGRAM WAS ALSO PERFORMED ON EACH CHILD DURING THE ENTIRE NIGHT TO DOCUMENT THE DIFFERENT STAGES OF SLEEP. ON DAY 2, EACH CHILD HAD THREE PROVOCATIVE TESTS, I.E. ARGININE, INSULIN AND L-DOPA OR CLONIDIN SIX OUT OF THE EIGHTEEN CHILDREN WITH CLASSIC GH DEFICIENCY WOULD HAVE BEEN MISSED IN 1/3 (6/18) OF THE CHILDREN WITH CLASSIC GH DEFICIENCY IF ONLY THE NOCTURNAL GH LEVELS WERE OBTAINED. THIS STUDY SUGGESTS THAT THE STUDY OF THE LEVELS OF GH DURING SLEEP DOES NOT ALWAYS REFLECT THE TRUE STATUS OF GH SECRETION IN CHILDREN AND THAT THE STUDY OF GH LEVELS DURING THE ENTIRE TWENTY -FOUR PERIOD IN CONJUNCTION WITH THE GH PROVOCATIVE TESTS MAY BE THE BEST WAY TO DIAGNOSE THE ABNORMALITIES OF GH SECRETION IN CHILDREN.

Grantor dc:publisher

University of Patras

Year dc:date

1987

Author dc:creator

• Γκρέκα-Σπηλιώτη, Μπέσση

• Ανεπάρκεια αυξητικής ορμόνης
• Αυξητική ορμόνη
• ΝΥΚΤΕΡΙΝΗ ΑΥΞΗΤΙΚΗ ΟΡΜΟΝΗ
• Ύπνος
• Growth hormone
• Growth hormone deficiency
• NOCTURNAL GROWTH HORMONE
• Sleep
• Ιατρική και Επιστήμες Υγείας
• Κλινική Ιατρική
• Medical and Health Sciences
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0464

OAI identifier oai:identifier

oai:10442/0464