ΠΕΙΡΑΜΑΤΙΚΗ ΟΞΕΙΑ ΠΑΓΚΡΕΑΤΙΤΙΔΑ ΜΕ ΤΗ ΜΕΘΟΔΟ ΤΗΣ ΚΛΕΙΣΤΗΣ ΔΩΔΕΚΑΔΑΚΤΥΛΙΚΗΣ ΕΛΙΚΑΣ

AIM OF THIS EXPERIMENTAL STUDY WAS THE EVALUATION OF THE ROLE OF BILE AND GASTRIC JUICE IN THE PATHOGENESIS OF ACUTE PANCREATITIS INDUCED BY THE CLOSED DUODENAL LOOP TECHNIQUE. THE EXPERIMENTS WERE PERFORMED IN TWO STEPS IN ORDER TO AVOID OBSTRUCTIVE JAUDICE, AND MINIMIZE ISCHAEMIA AND TRAUMA. AFTER LIGATION ABOVE (WHEN IT NEEDED) AND BELOW THE MAJOR AND MINOR DUODENAL PAPILLAS, A CLOSED DUODENAL LOOP CONSTRUCTED IN 24 MONGREL DOGS, DIVIDED INTO 4 GROUPS (6 ANIMALS IN EACH). IN THE ANIMALS OF THE 1ST GROUP (CONTROL) THAT WAS THE ONLY MANEUVER, BUTIN THE OTHER GROUPS ANOTHER OPERATION HAD PERFORMED IN A FIRST STEP FEW MONTHSAGO: IN THE 2ND GROUP A GASTRO-DUODENAL DISCONNECTION (DISTAL TO PYLORUS) FOLLOWED BY GASTROJEJUNOSTOMY WITH LONG AFFERENT LOOP; IN THE 3RD GROUP A DIVISION-LIGATION OF THE COMMON BILE DUCT, FOLLOWED BY A ROYX-EN-Y CHOLECYSTO-JEJUNOSTOMY; IN THE 4TH GROUP A COMBINATION OF THE OPERATIVE PROCEDURES USED IN THE 2ND AND 3RD GROUPS. ONE ANIMAL OF THE 1ST GROUP, 2 OF THE 2ND, NONE OF THE 3RD, AND 1 OF THE 4TH DEVELOPED ACUTE PANCREATITIS. IN ADDITION 2 ANIMALS IN EVERY GROUPDEVELOPED SOME INDICATIONS OF PANCREATIC DAMAGE (MINOR HISTOLOGICAL CHANGES INTHE PANCREAS, HYPERAMYLASAEMIA OR COMBINATION). OUR RESULTS SHOWED THAT: A. THE CONSTRUCTION OF THE CLOSED DUODENAL LOOP DID NOT SUCCEED, IN OUR EXPERIMENTS,FREQUENT DEVELOPMENT OF ACUTE PANCREATITIS. B. THE PRESENCE OF BILE IN THE CLOSED DUODENAL LOOP PREDISPOSES TO THE DEVELOPMENT OF ACUTE PANCREATITIS, WHILE THE PRESENCE OR PASSAGE OF GASTRIC JUICE THROUGH THE DUODENUM PROTECTS AGAINST ACUTE PANCREATITIS. C. THE EXPERIMENTAL MODEL USED IN OUR EXPERIMENTS, WHICH WASATRAUMATIC, IS OFFERED FOR FUTURE DEVELOPMENTS AND STUDIES ON THE AETIOLOGICALFACTORS OF ACUTE PANCREATITIS.

Grantor dc:publisher

University of Ioannina

Year dc:date

1987

Authors dc:creator

• Katsios, Christos
• Κάτσιος, Χρήστος

• Bacteria
• Bile
• CLOSED DUODENAL LOOP
• EXPERIMENTAL ACUTE PANCREATITIS
• GASTRIC JUICE
• PATHOGENESIS OF ACUTE PANCREATITIS
• Γαστρικό υγρό
• ΚΛΕΙΣΤΗ ΔΩΔΕΚΑΔΑΚΤΥΛΙΚΗ ΕΛΙΚΑ
• Μικρόβια
• ΠΑΘΟΓΕΝΕΙΑ ΟΞΕΙΑΣ ΠΑΓΚΡΕΑΤΙΤΙΔΑΣ
• ΠΕΙΡΑΜΑΤΙΚΗ ΟΞΕΙΑ ΠΑΓΚΡΕΑΤΙΤΙΔΑ
• Χολή
• Ιατρική και Επιστήμες Υγείας
• Κλινική Ιατρική
• Medical and Health Sciences
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0456

OAI identifier oai:identifier

oai:10442/0456