ΤΟ ΕΠΙΠΕΔΟ ΤΟΥ 2,3-ΔΙΦΩΣΦΟΡΟΓΛΥΚΕΡΙΝΙΚΟΥ ΟΞΕΩΣ ΤΩΝ ΕΡΥΘΡΩΝ ΑΙΜΟΣΦΑΙΡΙΩΝ ΣΤΗΝ ΔΡΕΠΑΝΟΚΥΤΤΑΡΙΚΗ ΝΟΣΟ

THE LEVEL OF 2,3 DPG WAS DETERMINED IN 5 GROUPS OF SUBJECTS: I) IN 32 CONTROL-SUBJECTS; II) IN 18 PATIENTS WITH SICKLE-CELL ANEMIA; III) IN 23 PATIENTS WITHSICKLE-THALASSEMIA; IV) IN 51 INDIVIDUALS WITH SICKLE-CELL TRAIT AND V) IN 18INDIVIDUALS WITH B-THALASSEMIA TRAIT. IN GROUP I, 2,3 DPG LEVEL WAS SIGNIFICANTLY HIGHER IN WOMEN THAN IN MEN AND A NEGATIVE LINEAR RELATIONSHIP WAS FOUND BETWEEN THE VALUES OF 2,3 DPG AND THOSE OF HEMOGLOBIN, HEMATOCRIT AND RED BLOOD CELL (RBC) COUNT. IN GROUPS II-V A SIGNIFICANT INCREASE IN THE CONCENTRATIONOF 2,3 DPG WAS NOTED IN COMPARISON WITH THE CONTROL GROUP; AN EXCEPTION WAS SEEN IN GROUP V WHEN THE 2,3 DPG LEVEL WAS EXPRESSED IN MM/10 9 RBC. IT IS SUGGESTED THAT IN B-THALASSEMIA CARRIERS THE CONCENTRATION OF 2,3-DPG IS DETERMINED BY THE NUMBER OF RBC'S AND THAT THE INCREASED CONCENTRATION OF 2,3 DPG IN SICKLE-CELL CARRIERS MAY BE EXPLAINED BY A DIMINISHED SATURATION OF HEMOGLUBIN WITH OXYGEN IN THE ARTERIAL BLOOD.

Grantor dc:publisher

National and Kapodistrian University of Athens

Year dc:date

1986

Author dc:creator

• Πέτσος, Παναγιώτης

• Δρεπανοκυτταρική αναιμία
• Δρεπανοκυτταρική νόσος
• ΚΑΜΠΥΛΗ ΣΥΝΔΕΣΕΩΣ ΟΞΥΓΟΝΟΥ-ΑΙΜΟΣΦΑΙΡΙΝΗΣ
• ΣΥΓΓΕΝΕΙΑ ΑΙΜΟΣΦΑΙΡΙΝΗΣ-ΟΞΥΓΟΝΟ SICKLE CELL DISEASE
• Anaemia
• Sickle cell anaemia
• THE OXYGEN AFFINITY OF THE HAEMOGLOBIN
• THE OXYGEN DISSOCIATION CURVE
• Ιατρική και Επιστήμες Υγείας
• Κλινική Ιατρική
• Medical and Health Sciences
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0414

OAI identifier oai:identifier

oai:10442/0414