ΚΙΝΗΤΙΚΗ ΤΗΣ ΚΕΦΑΔΡΟΞΙΛΗΣ ΣΤΟ ΜΗΤΡΙΚΟ ΓΑΛΑ. ΕΠΙΔΡΑΣΗ ΣΤΗ ΜΙΚΡΟΒΙΑΚΗ ΧΛΩΡΙΔΑ ΤΟΥΣΤΟΜΑΤΟΦΑΡΥΓΓΑ ΚΑΙ ΤΟΥ ΕΝΤΕΡΟΥ ΣΤΟ ΝΕΟΓΕΝΝΗΤΟ ΠΟΥ ΘΗΛΑΖΕΙ

CEFADROXIL IS AN ORAL CEPHALOSPORIN WITH HIGHER LIPID SOLUBILITY THAN OTHER MEMBERS OF THIS GROUP OF ANTIBIOTICS. IN A PREVIOUS STUDY IT HAS BEEN SHOWN THAT CEFADROXIL PRODUCES HIGHER ANTIBIOTIC CONCENTRATIONS IN HUMAN MILK. IN ORDER TO INVESTIGATE WHETHER THESE CONCENTRATIONS HAD ANY EFFECT ON CHANGING THE ORAL AND INTESTINAL FLORA OF BREAST-FED BABIES, THE AEROBIC BACTERIAL FLORA OF 60 NEWBORN BABIES WERE STUDIED. BABIES WERE DIVIDED IN TWO GROUPS, GROUP A CONSISTED OF 30 BREAST-FED BABIES BORN TO MOTHERS UNDER 1,0 G. OF ORAL CEFADROXIL ADMINISTERED B.I.D. FROM DAY 3 TO DAY 6 AFTER DELIVERY, WHEREAS GROUP B OF 30 BREAST-FED BABIES WERE USED AS CONTROL. AFTER THE FIRST DOSE CONCENTRATIONS OF CEFADROXIL IN BREAST-MILK WERE BACTERICIDAL TWO HOURS AFTER ADMINISTRATION, RANGING FROM 0,5 MG/ML TO 2,4 MG/ML AT 6 HOURS. THEY REMAINED BACTERICIDAL FOR THE WHOLE 8HOUR PERIOD AFTER THE LAST DOSE, RANGING FROM 1,2 MG/ML TO 4,4 MG/ML AT 6 HOURS. BACTERIAL CULTURES WERE TAKEN FROM EACH BABY ON THE THIRD AND SIXTH DAY OF LIFE. NEISSERIA CATARRHALIS WAS THE PREDOMINANT ORAL FLORA IN MOST OF THE NEWBORNS AT 3RD DAY OF LIFE, WHILE STREPTOCOCCUS VIRIDANS WAS THE PREDOMINANT AT DAY 6 OF LIFE. STREPTOCOCCUS PNEUMONIAE WAS THE ONLY ORGANISM REDUCED IN MOST OF THE NEWBORNS BREAST FED FROM MOTHERS UNDER CEFADROXIL TREATMENT. GRAM NEGATIVE BACTERIA WERE VERY RARELY FOUND AMONG THE ISOLATES OF THE ORAL FLORA WHEREAS E. COLI WAS PREDOMINANT IN THE INTESTINAL FLORA. CHANGES OF THE AEROBIC BACTERIAL FLORA DID NOT DIFFER FROM THOSE OBSERVED IN THE CONTROL GROUP.

Grantor dc:publisher

National and Kapodistrian University of Athens

Year dc:date

1985

Author dc:creator

• Χειρίδης, Κωνσταντίνος

• Γυναικολογία
• ΚΦ-ΚΕΦΑΔΡΟΞΙΛΗ
• Μητρικό γάλα
• Παιδιατρική
• Ιατρική και Επιστήμες Υγείας
• Κλινική Ιατρική
• Βασική Ιατρική
• Medical and Health Sciences
• Clinical Medicine
• Basic Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0401

OAI identifier oai:identifier

oai:10442/0401