Η ΝΕΦΡΙΚΗ ΣΥΜΜΕΤΟΧΗ ΣΤΗ ΜΙΚΡΟΔΡΕΠΑΝΟΚΥΤΤΑΡΙΚΗ ΑΝΑΙΜΙΑ

RENAL FUNCTION STUDIES WERE PERFORMED IN 41 PATIENTS WITH SICKLE CELL- BETA THALASSEMIA (S/B THAL) IN COMPARISON TO 14 NORMAL CONTROLS AND 8 SICKLE CELL (S/S) PATIENTS. POLYURIA, HYPOSTHENURIA AND MILD PROTEINURIA WERE COMMON IN BOTH S/B AND S/S PATIENTS. A RENAL CONCENTRATING DEFECT WAS MANIFEST IN ALL AND AN ABONORMAL ACIDIFICATION TEST WAS FOUND IN MOST PATIENTS STUDIED. A STATISTICALLY SIGNIFICANT NEGATIVE CORRELATION WAS NOTED BETWEEN CREATININE CLEARANCE (C CR) AND AGE FOR THE PATIENTS OVER 30 YEARS. THERE WAS NO CORRELATION BETWEEN HB AND C CR ON THE CONTRARY, A STATISTICALLY SIGNIFICANT NEGATIVE CORRELATION WAS FOUND BETWEEN C CR AND HBF. OUR S/B AND S/S PATIENTS SHOWED LOWER SERUM AND URINE MAGNESIUM LEVELS THAN DID NORMAL CONTROLS. ONE THIRD OF OUR PATIENTS SHOWED HYPERURICOURIA AND A STATISTICALLY SIGNIFICANT NEGATIVE CORRELATION WAS NOTED BETWEEN SERUM URIC ACID AND ITS FRACTIONAL CLEARANCE. SERUM PHOSPHATE LEVELS CORRELATED SIGNIFICANTLY TO THE TUBULAR REABSORPTIVE CAPACITY FOR PHOSPHATE; A STATISTICALLY SIGNIFICANT POSITIVE CORRELATION WAS FOUND BETWEEN THIS AND THE NUMBER OF PAINFUL CRISES PER YEAR.

Grantor dc:publisher

National and Kapodistrian University of Athens

Year dc:date

1986

Authors dc:creator

• Kontessis, Panagiotis
• Κοντέσης, Παναγιώτης

• Μικροδρεπανοκυτταρική αναιμία
• Νεφρική λειτουργία
• Renal function
• SICKLE CELL-BETA THALASSEMIA
• Ιατρική και Επιστήμες Υγείας
• Κλινική Ιατρική
• Medical and Health Sciences
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0383

OAI identifier oai:identifier

oai:10442/0383