An Investigation into the Role of Dietary Copper and Zinc on Copper/Zinc Cellular Bioavailability, Inflammation, and Species Typical Behaviors in a Late Onset Mouse Model of Alzheimer’s Disease

Research in the field of Alzheimer’s disease (AD) often focuses on the early onset form (EOAD); however, the majority of AD cases are late onset (LOAD). The reason for this is the genetic nature of EOAD, and thus relative ease of developing animal models for EOAD through genetic manipulation. The present study was an attempt to model LOAD in mice by crossing the J20 mouse, which overexpresses human mutated amyloid precursor protein (hAPP), with the ApoE4 mouse, which expresses the E4 allele of the apolipoprotein, resulting in J20/E4 offspring. The E4 allele is the only known genetic risk factor for the development of LOAD.

Author

• Boggs, Katelyn Nicole

• Neurosciences
• Alzheimer's disease
• ApoE4
• APP
• Burrowing
• Nesting

Identifier

hdl:1920/11153

OAI identifier oai:identifier

oai:MARS:1920/11153