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East Tennessee State University
Synthesis of Marine Chemicals and Derivatives as Potential Anti-Cancer Drugs.
Abstract
dc:description.abstract<p>Two natural marine compounds, 3-bromo-4,5-dihydroxybenzaldehyde <b>2</b> and 2,3-dibromo-4,5-dihydroxybenzaldehyde <b>5</b> together with two novel derivatives, 3-bromo-5-(tert-butyl-dimethyl-silanyloxy)-4-hydroxybenzaldehyde <b>3</b> and 1-bromo-2,3-dimethoxy-5-nitrooxy-methylbenzene <b>9</b>, were synthesized. Compounds <b>2</b>, <b>3</b>, and <b>5</b> were evaluated for their biological activity towards the inhibition of prostate cancer cell growth using staurosporine a a positive control. All three compounds have shown significant inhibition of prostate cancer cell growth. Compound <b>9</b> is yet to be evaluated.</p>
Degree
thesis:*- Name thesis:degree_name
- MS (Master of Science)
- Level thesis:degree_level
- Thesis - unrestricted
- Discipline thesis:degree_discipline
- Chemistry
- Year dc:date.issued
- 2008
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Bannerman-Akwei, Laude
Subjects
dc:subject × 8Rights
dc:rights- Statement dc:rights
-
- Copyright by the authors.
Identifiers
dc:identifier.*- Repository record dc:identifier
- https://dc.etsu.edu/etd/1990
- OAI identifier oai:identifier
- oai:dc.etsu.edu:etd-3342