Behavioral Changes in Adult C57BL/6J Mice following Prenatal Exposure to Ethanol.

<p>Fetal Alcohol Syndrome (FAS) labels children with physical, mental and behavioral deficits exposed to alcohol <em>in utero</em>. Current research indicates that timing of alcohol exposure of the embryo/fetus is a critical determinant of the behavioral deficits associated with FAS. This study represents a model for binge drinking, in which C57BL mouse embryos were exposed to alcohol during 2 separate critical periods of brain development, gestational day (GD) 7 or 8. As adults, the offspring were tested to determine if loco-motor activity and emotional reaction to a novel environment had been affected. Significant differences due to treatment and sex were noted for both the number of urinations (p=.005 and .001, respectively) and fecal boli (p=.011 and .001, respectively). These results suggest that the quantity of alcohol exposure <em>in utero</em> on the developing brain as in this binge-drinking model is critical in terms of adverse effects on behavioral outcome for the offspring.</p>

Name thesis:degree_name

MS (Master of Science)

Level thesis:degree_level

Thesis - unrestricted

Discipline thesis:degree_discipline

Biomedical Sciences

Year dc:date.issued

2001

Author dc:creator

• Nunley, Kevin Wade

• Ethanol Exposure
• C57BL/6J Mice
• Behavioral Defecits
• Medical Sciences
• Medicine and Health Sciences

Statement dc:rights

• Copyright by the authors.

Repository record dc:identifier

https://dc.etsu.edu/etd/46

OAI identifier oai:identifier

oai:dc.etsu.edu:etd-1096