East Tennessee State University
Antibiotic Resistance: Multi-Drug Profiles and Genetic Determinants.
Abstract
dc:description.abstract<p>Antimicrobial susceptibility profiles were assembled for isolates of <em>Moraxella catarrhalis</em> collected from the Mountain Home Veteran's Affairs Medical Center (VAMC) clinical laboratory in Johnson City, Tennessee. The goal of the study was to identify isolates for genetic characterization using comparisons of susceptibility profiles. Isolates of <em>Moraxella catarrhalis</em> collected from July 1984 through 1994 were analyzed for β-lactamase production using a Cefinase disk assay.</p> <p>A multi-drug profile consisting of 11 β-lactam antibiotics was performed on the 41 <em>M. catarrhalis</em> isolates. Kirby Bauer disk assays were performed for 7 cephalosporin and 4 non-cephalosporin antibiotics.</p> <p>In summary, 2 observations implicate more complex resistance determinants than the 2 known forms of the BRO β-lactamase. First, there was overlap in the ranges of inhibition zones. Second, several isolates had antibiotic-specific deviations from typical profiles. These data suggest either more variation in the <em>M. catarrhalis</em> BRO β-lactamase than described or contributions to resistance from undescribed determinants.</p>
Degree
thesis:*- Name thesis:degree_name
- MS (Master of Science)
- Level thesis:degree_level
- Thesis - unrestricted
- Discipline thesis:degree_discipline
- Biology
- Year dc:date.issued
- 2001
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Taylor, LaShan Denise
Subjects
dc:subject × 6Rights
dc:rights- Statement dc:rights
-
- Copyright by the authors.
Identifiers
dc:identifier.*- Repository record dc:identifier
- https://dc.etsu.edu/etd/43
- OAI identifier oai:identifier
- oai:dc.etsu.edu:etd-1093