Abstract
dc:description.abstractChapter one is split into three sections, providing general overviews of synthetic retinoids and their biology, Pd-catalysed C-C bond forming reactions and transition metal-catalysed borylation of aromatic and vinylic C-H bonds, respectively. Chapter two details the application of sequential Ir-catalysed aromatic C-H borylations, Pd-catalysed C-C bond forming reactions and Rh-catalysed vinylic C-H borylations for the stereo-controlled synthesis of stilbene-based TTNPB retinoids. Chapter three details the application of Ir-catalysed aromatic C-H borylations, Sonogashira cross-couplings and Suzuki-Miyaura cross-couplings for the synthesis of tolan-, and biaryl-based retinoids. Chapter four details the development and applications of new RhI catalyst precursors for the dehydrogenative borylation of unactivated olefins. The dehydrogenative borylation reactions were utilised in one-pot, single solvent syntheses of 2-arylindenes from indene and arylhalides through C-H borylation and subsequent Suzuki-Miyaura cross-couplings.
Degree
thesis:*- Name dc:type.qualificationname
- PhD
- Level dc:type.qualificationlevel
- doctoral
- Grantor dc:publisher.institution
- Durham University
- Year dc:date.issued
- 2010
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Barnard, Jonathan Harold