Synthesis of Novel 6-Substituted and 5-Substituted Pyrrolo[2,3-D] Pyrimidine Antifolates as Targeted Anticancer Therapies

<p>The dissertation will give an introduction, background and current research progress in the areas of antifolates and chemotherapy of anticancer. The design and synthesis of classical 6- substituted pyrrolo[2,3-<em>d</em>]pyrimidines and 5-substituted pyrrolo[2,3-<em>d</em>]pyrimidines as potential antifolates have been described. The design variations include: methylated thiophene regioisomers, fluorinated phenyl regioisomers, thionyl regioisomers on the side chain of pyrrolo[2,3-<em>d</em>]pyrimidines. As a part of this study, a series of new compounds have been synthesized and characterized. Of these, ten final compounds were submitted for biological evaluation.</p>

Name thesis:degree_name

MS

Level thesis:degree_level

One-year Embargo

Discipline thesis:degree_discipline

Medicinal Chemistry

Year dc:date.available

2018

Author dc:creator

• Li, Xinxin

Contributors dc:contributor

• Aleem Gangjee
• Marc W. Harrold
• Kevin Tidgewell

• ANTIFOLATES PYRROLO[2
• 3-d] PYRIMIDINE
• Medicinal and Pharmaceutical Chemistry

Language dc:language

English

Repository record dc:identifier

https://dsc.duq.edu/etd/1727

OAI identifier oai:identifier

oai:dsc.duq.edu:etd-2756