The interaction of xenobiotics and anaesthetic agents with hepatic microsomal stearate desaturase

This thesis comprises an investigation into the reaction of halogenated xenobiotics and anaesthetic agents, with hepatic microsomal stearate desaturase. The levels of stearate desaturase in the hepatic microsomes were routinely elevated by re-feeding the experimental animals a high carbohydrate diet. The interaction of the xenobiotics with stearate desaturase was assessed by monitoring their effects on the redox steady state of hepatic microsomal cytochrome b₅, in the presence and absence of cyanide.

Grantor dc:publisher.institution

Division of Medical Biochemistry and Structural Biology

Year dc:date.issued

1980

Author dc:creator

• Manca, Veronica

Advisors dc:contributor.advisor

• Harrison, Gaisford Gerald
• Ivanetich, Kathryn M

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/27512

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/27512