Utero-placental blood flow in hypertensive pregnancy and the effect of nifedipine administration

Nifedipine, in a 5mg sublingual acute administration, causes a significant fall in the systolic, diastolic and mean arterial pressure in a mixed group of pregnant hypertensives. A concurrent, significant rise in the pulse rate was seen. The utero-placental blood flow index, which is a measure of utero-placental blood flow, was not significantly reduced following the administration of Nifedipine or a placebo. The utero-placental blood flow index was found to be a consistent measure of utero-placental blood flow in resting patients. In the absence of serious side-effects it can be concluded that Nifedipine is a safe therapy in the acute treatment of hypertensive states in pregnancy.

Grantor dc:publisher.institution

Department of Obstetrics and Gynaecology

Year dc:date.issued

1987

Author dc:creator

• Lindow, S W

Advisor dc:contributor.advisor

• Davey, D A

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/27206

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/27206