Synthesis, antimalarial evaluation, Ç-hematin inhibition, and in silico and in vitro ADMET profiling of 4-aminoquinoline-hydroxypyridinone hybrids

With the aim of designing appropriate hybrid molecules as a strategy to fight drug resistant malaria parasites, 4-aminoquinoline-3,4-hydroxypyridinone hybrids were designed and synthesized. Their hypothesized mode of action was studied with respect to inhibition of hemozoin formation.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

2011

Author dc:creator

• Andayi, Warren Andrew

Advisors dc:contributor.advisor

• Chibale, Kelly
• Egan, Timothy J

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/14824

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/14824