Investigating cross-clade immune responses in HIV-1 subtype C-infected individuals from South Africa

The increasing diversity of HIV-1 in different geographic regions presents a challenge for the development of an HIV/AIDS vaccine. Even if proven effective, the ability of a vaccine to have cross-subtype and intra-subtype protection remains an important question. The aim of the study was to investigate cross- and intra-clade T cell immune responses in HIV-1 subtype C-infected individuals. The objectives were to genetically characterise full length gag gene sequences from individuals chronically infected with HIV-1 and then assess the degree of cross-reactive immune responses in an ELlS pot assay using peptide reagents based on vaccine candidates.

Grantor dc:publisher.institution

Division of Virology

Year dc:date.issued

2007

Author dc:creator

• Zembe, Lycias

Advisor dc:contributor.advisor

• Burgers, Wendy

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/12731

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/12731