Novel chemotherapeutic agents for oesophageal cancer

Chemotherapeutic agents such as cisplatin, doxorubicin and 5-fluorouracil are currently used in the treatment of a variety of cancers, including oesophageal cancer. Although these agents have been part of our therapeutic repertoire for many years, there are several side effects that have been associated with their use in cancer therapy. Thus there is a need to develop novel chemotherapeutic agents with improved activity and less severe side effects. In this project, twelve compounds, consisting of 5 platinum dichloride complexes, four iminophosphine ligands and three gold (I) chloride complexes that were synthesised by a PhD student in our laboratory were tested for anticancer activity and the mode of action of these compounds was also explored.

Grantor dc:publisher.institution

Division of Medical Biochemistry

Year dc:date.issued

2012

Author dc:creator

• Khuzwayo, Londiwe Mandisa

Advisor dc:contributor.advisor

• Hendricks, Denver

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/12051

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/12051