Investigations of mycobacteria-specific memoryy/effector T cell responses in HIV infected children receiving antiretroviral therapy

Human immunodeficiency virus (HIV) infected children are at greater risk of developing tuberculosis disease, and might benefit from vaccination with novel TB vaccines. However, little is known about the effect of HIV-infection on function and phenotype of T cell responses to mycobacterial antigens in children. This study compares both CD4 and CD8 T cell cytokine expression and memory phenotype in children, following in vitro stimulation with mycobacterial antigens, also contained in novel anti-TB vaccines that are currently undergoing clinical trials.

Grantor dc:publisher.institution

Institute of Infectious Disease and Molecular Medicine

Year dc:date.issued

2011

Author dc:creator

• Tena-Coki, Nontobeko Gwendoline

Advisors dc:contributor.advisor

• Hanekom, Willem
• Scriba, Thomas
• Kampmann, Beate

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/11689

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/11689