Action Potential Simulation of the Hirudo Medicinalis's Retzius Cell in MATLAB

<p>Modification of Hodgkin and Huxley’s experimentally derived set of nonlinear differential equations was implemented to accurately simulate the action potential of the <em>Hirudo Medicinalis’s</em> Retzius cell in <em>MATLAB</em> under analogous conditions to those found in the Retzius cell environment. The voltage-gated sodium and potassium channel responses to changes in membrane potential, as experimentally determined by Hodgkin and Huxley, were manipulated to suit simulation parameters established by electrophysiological Retzius cell recordings. Application of this methodology permitted additional accurate simulation of the <em>Hirudo Medicinalis’s</em> P cell under analogous conditions to those found in the P cell environment. Further refinement of this technique should allow for the voltage-gated behavioral based simulation of action potential waveforms found in variety of neurons under simulation conditions analogous to the nerve cell environment.</p>

Name thesis:degree_name

MS in Biomedical Engineering

Discipline thesis:degree_discipline

Biomedical and General Engineering

Year dc:date.available

2013

Author dc:creator

• Tempesta, Zechari Ryan

Contributors dc:contributor

• Robert B. Szlavik

• Retzius cell
• Hirudo medicinalis
• action potential
• electrophysiology
• computational simulation
• Hodgkin-Huxley Model
• Voltage-gated ion channels
• Biomedical Engineering and Bioengineering
• Computational Engineering

Identifier

10.15368/theses.2013.207

OAI identifier oai:identifier

oai:digitalcommons.calpoly.edu:theses-2197