Biophysical model of core & matrix thalamocortical circuitry in rodents & primates

The interactions between the cortex, thalamus and inhibitory thalamic reticular nucleus compose the thalamocortical system that is responsible for sensory processing and attention, during wakeful states, and sleep spindle generation, during sleep states. The TC system is divided into two sub-circuits, the core and matrix, the former involved with sensory processing, while the latter focused on limbic processing and memory consolidation. The core and matrix TC circuit is present in all species, both in open and closed loop fashions, but the composition of the circuit is not the same across rodents and primates. While the role of the corticothalamic system in sleep spindle generation is well established, the individual role of the core and matrix is not well understood in rodents and primates. Therefore, we created both a rodent and primate biophysical neural model of the core and matrix thalamocortical circuit. We found that the primate model was able to synchronize the network activity faster than the rodent model; primate TC relay neurons were less likely to sustain their activity, and primate matrix and mixed spindles had a higher amplitude than their rodent counterparts. The primate open-loop circuitry also produced higher spindle density. Therefore, the core and matrix thalamocortical circuit model of the rodent and primate was able to shed light into how these two species spindling patterns differ.

Author dc:creator

• Matuk, Natalia

Advisor dc:contributor.advisor

• Zikopoulos, Vasileios

• Neurosciences

Statement dc:rights

• Attribution-NonCommercial-NoDerivatives 4.0 International

Licence dc:rights.uri

• http://creativecommons.org/licenses/by-nc-nd/4.0/

Language dc:language.iso

en_US

Handle dc:identifier.uri

https://hdl.handle.net/2144/46296

OAI identifier oai:identifier

oai:open.bu.edu:2144/46296