Influence of plasma proteins on setting characteristics of mineral trioxide aggregate like cement

Mineral trioxide aggregate (MTA) is a modified Portland cement (PC) based dental material containing bismuth oxide (Bi2O3) as a radiopacifier that is presently used as a sealing material in endodontic treatment. The present study investigated the influence of albumin, fibrinogen and γ-globulin, the three most abundant blood plasma proteins, both individually and in combination on the setting time, compressive strength and relative porosity of an MTA-like dental cement. The cement powder formulation was mixed with the liquid phase containing normal plasma protein concentrations or quarter, double or quadruple the normal plasma protein concentration as well as a mixture of all three proteins. Compressive strength and relative porosity were measured from 2 to 56 days and the initial setting times were determined using the Gilmore needles test. The set cement microstructure was examined using scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX). The compressive strength of all cements increased with time whereas strut density and relative porosity decreased. Fibrinogen and γ-globulin increased setting time with increasing concentration while albumin acted as an accelerant. For the MTA model mixed with all three plasma proteins, the setting times decreased as concentrations were increased.

Name dc:type.qualificationname

m_ph

Level dc:type.qualificationlevel

m_ph

Grantor dc:publisher.institution

University of Birmingham

Year dc:date.issued

2010

Author dc:creator

• AbuOnq, Zaid

• RK Dentistry