Mainz
Strukturierung und Modifizierung von Polymeren mit UV-Laserstrahlung für life science Anwendungen
Abstract
dc:descriptionThe objective of this work was the development of new processing technologies with UV-laser radiation for high performance and biocompatible polymers in life science applications. The laser treated surfaces were characterized by a variety surface sensitive of methods. In these polymers different surface topologies were generated by ablation in order to study their wetting properties by measurement of water contact angles. With this protocol it was possible to generate a Lotus-effect on hydrophobic polymers like PDMS and an "anti"Lotus-Effect in more hydrophilic polymers like PEEK. No negative influence on the biocompatibility of polymer surfaces caused by laser treatment has been detected. Guided cell growth was stimulated along geometrically defined groves generated by laser ablation. Furthermore cells proliferate well through laser drilled holes. On PDMS the parameters for laser drilling of small geometrically defined holes were optimized and the holes were characterized. A special procedure based on the use of a protective coating was developed to avoid the build-up of debris around small structures. As an application of this methodology a laser drilled retina implant is described. The chemical changes on polymer surfaces caused by laser treatment in air have been examined on selected polymers. New functionalities generated by photo oxidation were identified by derivatization with fluorescent dyes. The functionalized micro structures were detected by florescence microscopy. Reactive compounds like azides were immobilized out of a solution surrounding the polymer onto its surface with high spatial resolution by use of laser radiation. This procedure for polymer surface modification might stimulate further research into the immobilization of bioactive molecules e.g. for applications in biochips.
Degree
thesis:*- Grantor dc:publisher
- Mainz
- Year dc:date
- 2004
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Bremus-Köbberling, Elke Auguste
- Contributors dc:contributor
-
- Höcker, Hartwig
Subjects
dc:subject × 5Rights
dc:rights- Statement dc:rights
-
- info:eu-repo/semantics/openAccess
- Language dc:language
- ger
Identifiers
dc:identifier.*- OAI identifier oai:identifier
- oai:publications.rwth-aachen.de:62017