Publikationsserver der RWTH Aachen University
Effekte von Iloprost auf Hämodynamik und Gasaustausch beim akuten Lungenversagen : eine tierexperimentelle Studie
Abstract
dc:descriptionARDS (acute respiratory distress syndrome) is characterized by an intrapulmonary mismatch between ventilation and perfusion, resulting in grave hypoxemia, pulmonary hypertension, high pulmonary right-to-left shunt and complex inflammatory events. In spite of modern proposals of therapy, it leads to a lethal disease pattern in many cases. Vasodilatores, especially their inhalational form of application, can decrease pulmonary artery pressure (PAP) and improve oxygenation by selective pulmonary vasodilation. This study evaluated the effect of iloprost in relation to hemodynamics and gas exchange in experimental acute lung injury (ALI) with a view to the decreasement of PAP by one-time application of iloprost. 12 pigs with acute lung injury, prospectivly randomized with inhaled iloprost in doses of 220 ng kg-1 min-1 or intravenous iloprost in doses of 80 ng kg-1 min-1 were medicated during a medication time of 15 minutes. A control group with 6 animals served as reference. Measurements of pulmonary gas excange and hemodynamics were taken during the experimental time. Of capital importance is that inhaled iloprost immediately leads to a temporary improvement of hemodynamics and time-delayed to an improvement of gas exchange. Due to the lack of congruency of these effects, a selective pulmonary vasodilation was not verifiable. Intravenous iloprost immediately causes a temporary improvement of hemodynamics without haveing any effects to gas exchange. A prolongued vasodilative effect was not ascertainable by the usage of the applied dosages, which would be the basis of discontinuos medication of iloprost in ARDS.
Degree
thesis:*- Grantor dc:publisher
- Publikationsserver der RWTH Aachen University
- Year dc:date
- 2004
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Rott, Axel
- Contributors dc:contributor
-
- Kuhlen, Ralf
Subjects
dc:subject × 6Rights
dc:rights- Statement dc:rights
-
- info:eu-repo/semantics/openAccess
- Language dc:language
- ger
Identifiers
dc:identifier.*- OAI identifier oai:identifier
- oai:publications.rwth-aachen.de:61902