Bluttraumatisierung bei der Passage zeitkonstanter und zeitvarianter Scherfelder

Until today the employment of artificial systems in human circulation is limited by their reduced blood compatibility. This is mainly dependend on flow conditions and the contact to artificial surfaces. In blood pumps or artificial heart valves high fluid mechanical stresses are dominating. This thesis reports about a systematic damage investigation under such conditions. In vitro blood damage experiments with labtypes of artificial systems only result in information on the overall damage since their flow fields are highly complex. A reliable correlation between certain flow regions and their damage contribution is not possible. Therefore a model system is presented that applies defined fluid stresses to human and porcine blood. The system is validated by investigations on flow and load conditions in the shear zone and separation effects between blood cells and plasma. Furthermore residence time distributions are experimentally and theoretically analysed. Subsequently the thesis reports about the performed in vitro experiments and the extensive blood analysis concerning different damage aspects: Hemolysis, platelet activation and generation of microparticles and microaggregates. The collected damage data and damage models that are derived from it allow an integration of damage behavior in computational fluid dynamic studies. This aims on a damage prognosis and preoptimization process for new developments of artificial systems already in the design phase.

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2004

Author dc:creator

• Klaus, Sebastian

Contributors dc:contributor

• Rau, Günter

• info:eu-repo/classification/ddc/620
• Ingenieurwissenschaften
• Künstliche Organe
• Mechanische Blutschädigung
• Schädigungsmodelle

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

ger

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-123465%22

OAI identifier oai:identifier

oai:publications.rwth-aachen.de:61845