Neuroprotektive Effekte von Rolipram und Zolpidem auf Sekundärläsionen der Substantia nigra nach chinolinsäureinduzierter Läsion des Striatums

In this study the susceptibility of neuronal death and of the expression of TNF ( in the substantia nigra pars recticulata by the GABA agonist zolpidem, and the phosphodiesterase inhibitor rolipram, after excitotoxic lesion of the striatum has been examined in a rat model for the neurodegenerative disorder Chorea Huntington. In a stereotactic operation, intrastriatal injections of chinolinic acid were applied to a total of 22 rats in order to achieve an excitotoxic lesion of the striatum. Afterwards the rats were treated according to three different groups: Group I has been examined for 14 days without further treatment. The second group has been administered neuroprotective treatment with either rolipram or zolpidem for 14 days beginning 24 hours after the striatal lesion was set. After 14 days Nissl-stains and immunohistochemical stains with GFAP and OX-42 antibodies have been made from the regions of the striatum and the substantia nigra of both groups. Based on the Nissl-stains a massive destruction of the striatum could be observed after chinolinic acid injection. By means of cell counts, a significant reduction of neuronal cell loss in the substantia nigra pars reticulata was found in the rolipram group. The treatment with zolpidem led to no significant change compared with the untreated group. In the third group the time course of TNF ( expression in the substantia nigra pars reticulata after excitotoxic striatal lesion was examined. A maximum expression was found between the first and the third day post laesionem.

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2005

Author dc:creator

• Frohn, Claas

Contributors dc:contributor

• Block, Frank

• info:eu-repo/classification/ddc/610
• Medizin
• Rolipram
• Zolpidem
• Morbus Huntington
• Substantia nigra
• Striatum
• Neurodegeneration
• transsynaptische Degeneration

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

ger

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-123444%22

OAI identifier oai:identifier

oai:publications.rwth-aachen.de:61823