T-Zell-unabhängige MHC-II-Signaltransduktion durch Superantigene

For a couple of years MHC-II complexes are known for many more assignments than antigen presentation. In this thesis the quite unknown mechanism of superantigen-induced T cell independent MHC-II-signaltransduction is investigated. It could be demonstrated that the superantigen-induced MHC-II-signaltransduction depends on the existence of lipid rafts. Another result was the finding that the proteinkinase C (PKC) pathway is involved in signaltransduction. Cell aggregation induced by the used anti-MHC-II-antibodies was not significantly decreased by blocking PKC. Furthermore the experiments show that there is no difference in cell aggregation by superantigens with homogenic or heteogenic binding sites for MHC-II, and that the superantigen-induced MHC-II-signaltransduction does not induce apoptosis.

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2006

Author dc:creator

• Groß, Ulrike

Contributors dc:contributor

• Rink, Lothar

• info:eu-repo/classification/ddc/570
• Biowissenschaften, Biologie
• MHC Klasse II
• Superantigen
• Signaltransduktion
• SEA
• MHC class II
• superantigene
• signaltransduction

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

ger

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-123220%22

OAI identifier oai:identifier

oai:publications.rwth-aachen.de:61566