Zytokeratinmuster zur Unterscheidung von odontogenen Zysten

The clinical outcome of treatment of odontogenic cysts differs depending on separate entities. Particular clinical relevance must be attached to the distinction between odontogenic keratocysts, which have an evident tendency to recur, and other odontogenic cysts. The aim of this study was to evaluate cytokeratin (CK) expression patterns as an additional tool for characterization of different cysts as the histomorphologic appearance often is not decisive.Thirty cases of dentigerous and radicular cysts respectively as well as 13 cases of odontogenic keratocysts were considered. Expression of CK 5/6, 7, 10, 13, 17, 19 and 20 was determined in addition to Ki-67 immunohistochemically. Expression of CK 17 was discernible in 92,3% of the odontogenic keratocysts, but only in 33,3% of dentigerous and 40% of radicular cysts under study (P < 0.001). CK 19 could be detected in 46,7% of dentigerous and radicular cysts, whereas odontogenic keratocysts were completely negative (p<0,002).Immunohistochemical detection of CK 17 and 19 seems to be a valuable additional parameter distinguishing between odontogenic keratocysts and other odontogenic--especially dentigerous--cysts which clinically are likely the most significant differential diagnoses in this context.

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2005

Author dc:creator

• Stollenwerk, Carolin

Contributors dc:contributor

• Stoll, Christian

• info:eu-repo/classification/ddc/610
• Medizin
• Zyste
• Cytokeratine
• odontogen
• odontogene
• Keratozyste
• follikuläre
• radikuläre
• odontogenic
• cyst

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

ger

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-122516%22

OAI identifier oai:identifier

oai:publications.rwth-aachen.de:60828