Synthesis of new sulfoximines for asymmetric synthesis and pseudopeptides

Sulfoximines have attracted attention due to their applicability as chiral auxiliaries, ligands in asymmetric catalysis, and building blocks in pseudopeptides. A number of approaches have been investigated for their synthesis, which allows the preparation of various derivatives in a relatively straightforward manner. In order to extend the research in this area, it is essential to develop methods, which make a wide variety of enantiomerically pure sulfoximine derivatives accessible. This thesis is mainly centered on the search of new synthetic methodologies and the improvement of existing ones in order to prepare a variety of sulfoximine compounds conveniently. The strategies for these intentions involve: (i) aryl substitution on sulfoximines by palladium-catalyzed cross coupling, (ii) a-functionalization of sulfoximines by palladium-catalyzed C-arylation, (iii) copper-mediated N-arylation of sulfoximines and (iv) silver-catalyzed or metal-free iminations of sulfoxides to afford sulfoximines.

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2006

Author dc:creator

• Cho, Gae Young

Contributors dc:contributor

• Bolm, Carsten

• info:eu-repo/classification/ddc/660
• Asymmetrische Synthese
• Sulfoximin
• Katalyse
• Technische Chemie
• Kreuzkupplung
• Iminierung
• Silberkatalyse
• Cross-coupling
• imination
• silver catalysis

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

eng

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-122508%22

OAI identifier oai:identifier

oai:publications.rwth-aachen.de:60820