Fatigue und Lebensqualität bei Patienten mit chronischer Hepatitis C

Fatique is the persistent psychic as well as physically felt tiredness and exhaustion. This symptom goes along with a serious restriction of the quality of life and is often observed with patients with a chronic liver illness. The objective of this work is to examine the fatigue symptom and its influence on the quality of life, psychic load and cognitive abilities with patients with chronic hepatitis C. In the present study 46 patients with chronic hepatitis C, 13 patients with chronic hepatitis B, 22 patients with not virale hepatitis were enclosed and compared to control group with a chronically not hepatic illness 32 patients with a chronically inflammatory intestinal illness (Morbus Crohn or Colitus ulcerosa). A second control group consists of 38 healthy test persons. Patients and controls completed an self-report questionnaire with a total of 11 different tests (3 tiredness tests: Visual Analog Scale, Fatigue Severity Scale, Fatigue Impact Scale; 2 tests for the judgement of psychic load: Beck Depression Inventory, Symtom Check Liste; 1 test for the judgement of cognitive deficits: Fragebogen erlebter Aufmerksamkeitsdefizite; 5 tests for the judgement of the quality of life: Modulares System zur Lebensqualität, Fragen zur Lebenszufriedenheit, Nottingham Health Profile, Befindlichkeitsliste, Beschwerdeliste). As a function of subjectively felt tiredness the evaluation occurred for every illness group after allocation of the patients in subgroups with and without subjective tiredness. Regardless of the etiology of the illness, 50-60% of all patients showed a subjective fatigue symptom, which could well be proved in the fatigue tests. Therefore the tiredness is neither liver nor hepatitis C specific, but can appear as a result of a chronic illness. Subjectively felt tiredness leads in the Fatigue Impact Scale to an interference of the physical, cognitive and psychosocial functions. The chronically inflammatory intestinal illness shows in comparison to chronic liver illness regardless of the tiredness a decrease of the energy and physical interference. Subjective tiredness and depression show moderate to good correlation for patients with chronic hepatitis C and not virale hepatitis. In contrast, a depression independent of the subjective tiredness was ascertained moreover with the chronically inflammatory intestinal illness. The cognitive efficiency showed in the group of the chronic hepatitis C with subjective tiredness the highest self-experienced deficits. Cognitive interferences also show the comparative group of the Morbus of Crohn/Colitis patients, so that these deficits are not specific for liver. An interference of most aspects of the quality of life was to be observed with chronic hepatitis C only in the subgroup with subjective tiredness, while the subgroup without tiredness does not differ in the quality of life from a healthy control group. Besides, an increase of the depression and the tiredness resulted in a clear reduction of the quality of life. However, a restriction of the quality of life also counts to the other forms of the chronic hepatitis C if a subjective tiredness persist. The patients without tiredness are essentially not limited in their quality of life in spite of their chronic liver illness. By contrast a decrease of the quality of life can be ascertained in the comparative group of the chronically inflammatory intestinal illnesses widely independently of the subjective tiredness. Hence, for the diagnostics and therapy of the chronic hepatitis C illness it is crucial to recognize depressive symptoms and mental changes with the patients, because an important role comes up to them in the pathogeny of the tiredness.

Grantor dc:publisher

Publikationsserver der RWTH Aachen University

Year dc:date

2005

Author dc:creator

• Güner-Capraz, Nesrin

Contributors dc:contributor

• Matern, Siegfried

• info:eu-repo/classification/ddc/610
• Medizin
• Fatigue
• Hepatitis C
• Lebensqualität
• psychische Störungen
• kognitive Störungen

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

ger

Identifier

https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-122462%22

OAI identifier oai:identifier

oai:publications.rwth-aachen.de:60772