Publikationsserver der RWTH Aachen University
Zum Einfluß von Dialysemembranmaterialien auf den [beta]-2-Mikroglobulinspiegel unter Hämodialyse
Abstract
dc:descriptionA serious late effect in the dialsysis treatment is the dialysis associated amyloidosis as a result of accumulation of beta2-M in the serum. Aim of this study was to examine if the beta2-M concentration in blood can be reduced by dialysator-membranes with different permeability and adsorption capacity. For this purpose the following experiments have been carried out: 1. Determination of beta2-M-Clearance during dialysis with cuprophane- and PMMA-membranes. 2. Reduction of beta2-M-concentration in 9 different high-flux- and low-flux-membranes during a dialysis treatment. 3. Observation of beta2-M-concentration during one year of dialysis treatment using 4 different membrane-types at 10 patients each. The experiments show that neither the low-flux-membrane cuprophane nor the low-flux-membrane polysulfone are able to remove beta2-M from the serum of patients. Synthetic high-flux-membranes like polysulfone, polyamid and polymethylmethacrylat (PMMA) however are able to reduce the beta2-M-level during dialysis but without reaching normal results. Among these the PMMA-membrane possibly has the best effects because of its adsorptive capacity. This is demonstrated best in the long-term treatment. With this membrane a clearance of ca. 39ml/min can be reached. Although there is an elimination by synthetic membranes the predialytic concentration of beta2-M in blood is only little lower compared with non-eliminating membranes. Non of the examined membranes is able to normalize the concentration of beta2-M in serum. Because of the small number of cases and the short time of observation it is not possible to give evidence if by a minimal improvement of the elimination of beta2-M by synthetic high-flux-membranes the genesis of dialysis-associated amyloidosis is slowed down or prevented.
Degree
thesis:*- Grantor dc:publisher
- Publikationsserver der RWTH Aachen University
- Year dc:date
- 2003
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Koch, Antje
- Contributors dc:contributor
-
- Mann, Helmut
Subjects
dc:subject × 6Rights
dc:rights- Statement dc:rights
-
- info:eu-repo/semantics/openAccess
- Language dc:language
- ger
Identifiers
dc:identifier.*- OAI identifier oai:identifier
- oai:publications.rwth-aachen.de:59347